8-Hydroxy-5,6,7-trimethoxy-2-phenyl-4H-chromen-4-one
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چکیده
In the title compound, C(18)H(16)O(6), the benzopyran group is essentially planar, with the O atoms of the substituent groups lying close to its mean plane. The mol-ecular conformation is governed by intra-molecular inter-actions. The crystal packing is mainly determined by one classical inter-molecular hydrogen bond which gives rise to the formation of an infinite chain along the a axis.
منابع مشابه
6,8-Dibromo-5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate
In the title compound, C(17)H(10)Br(2)O(5), the chromene ring is almost planar with minimal puckering [total puckering amplitude = 0.067 (4) Å]. The dihedral angle between chromeme ring system and phenyl ring is 3.7 (2)°. The crystal structure is stabilized by intermolecular C-H⋯O inter-actions and an intramolecular O-H⋯O hydrogen bond also occurs.
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In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity. In vitro COX-1/COX-2 isozyme inhibition structure-activity studies identified 3-(benzyloxy)-2-[4-(methylsulfonyl)ph...
متن کامل5-Hydroxy-7-methoxy-4H-chromen-4-one
The mol-ecular conformation of the title compound, C(10)H(8)O(4), isolated from Laretia acualis, is stabilized by a strong intra-molecular hydrogen bond between the hydroxyl and carbonyl groups. The crystal packing shows π-π stacking inter-actions. The chromene (4H-1-benzopyran-4-one) unit is essentially planar.
متن کامل3,5,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
In the title compound, C(19)H(18)O(6), also known as 3,4',5,7-tetra-methoxy-flavone, the dihedral angle between the benzopyran-4-one group and the attached benzene ring is 11.23 (8)°. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal, mol-ecules are linked into a two-dimensional network parallel to (01) by inter-molecular C-H⋯O hydrogen bonds, which generate R(...
متن کامل(E)-3,4,5-Trimethoxy-N′-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide
In the title chromone-tethered benzohydrazide derivative, C20H18N2O6, the atoms of the E-3-(hydrazonometh-yl)-4H-chromen-4-one segment are essentially coplanar, the largest deviation being 0.065 (6) Å. The dihedral angle between this segment and the benzene ring of the tri-meth-oxy-benzene unit is 40.18 (10) Å. In the crystal, the mol-ecule is linked to its inverse-symmetry equivalent by pairs ...
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